Indol-2-one derivatives

Details Indol-2-one derivatives Indol-2-one derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/404 (2006.01) A61K 31/4439 (2006.01) C07D 209/34 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2193039

A pharmaceutical compound of the formula Image in which R1 and R2 are each hydrogen, C1-4 alkyl, C1-4 alkoxy, HO-C1-4 alkyl, C1-4 alkoxy-C1-4 alkyl, C1-4 alkylthio, halo or PhCR'R'' - where Ph is optionally substituted phenyl and R' and R " are each hydrogen or C1-4 alkyl, or R1 and R2 together with the carbon atom to which they are attached form a C3-6 cycloalkyl group, R3, R4 and R5 are each hydrogen, halo, nitro, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkyl-CO-, C1-4 alkyl-S (O)m- where m is 0, 1 or 2, R'R " N-SO2-, -COOR', -CONR'R " , -NR'R " , -N(OR')COOR ", -COR', -NHSO2R', where R' and R " are each hydrogen or C1-4 alkyl, R6 and R7 are each hydrogen or C1-4 alkyl, and n is 1 to 6, X is oxygen or sulphur, W is Image where p is 4 to 7, and q and r are each 1 to 3, Y is Image and Z is optionally substituted phenyl or optionally substituted heteroaryl; and salts and esters thereof; and their use in the treatment of disorders of the central nervous system.

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