Indol-3-carbonyl-spiro-piperidine derivatives as v1a...

C - Chemistry – Metallurgy – 07 – D

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C07D 491/107 (2006.01) A61K 31/438 (2006.01) C07D 401/06 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2615726

This invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as Via receptor antagonists and which are represented by Formula (I): wherein the spiro-piperidine head group A and the residues R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, their use in medicaments against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders, and methods of preparation thereof.

L'invention concerne des dérivés de-3-yl-carbonyl-spiro-pipéridine agissant comme des antagonistes du récepteur Via et qui sont représentés par la formule (I). Dans cette formule, le groupe de tête A de spiro-pipéridine et les résidus R1, R2 et R3 sont comme définis dans le descriptif. L'invention concerne également des compositions pharmaceutiques contenant de tels composés et, outre des méthodes de préparation, leur utilisation dans des médicaments contre la dysménorrhée, l'hypertension, l'insuffisance cardiaque chronique, la sécrétion intempestive de vasopressine, la cirrhose du foie, le syndrome néphrotique, les troubles obsessionnels compulsifs et les troubles de l'angoisse et de la dépression.

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