Indol-3-yl-carbonyl-azaspiro derivatives as vasopressin...

C - Chemistry – Metallurgy – 07 – D

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C07D 491/10 (2006.01) A61K 31/4355 (2006.01) A61K 31/437 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2623715

This invention relates to indol-3-yl-carbonyl-azaspiro derivatives which act as Via receptor antagonists and which are represented by Formula (I) wherein the azaspiro-head group A and the residues R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, their use in medicaments against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxiety and depressive disorders, and methods of preparation thereof.

La présente invention concerne des composés indol-3-ylcarbonylazaspiro agissant en tant qu'antagonistes du récepteur V1a et qui sont représentés par la Formule (I), le groupement de tête azaspiro A et les résidus R1, R2 et R3 étant tels que définis dans la présente invention. La présente invention concerne en outre des préparations pharmaceutiques contenant de tels composés, leur emploi dans des médicaments contre la dysménorrhée, l'hypertension, les insuffisances cardiaques chroniques, la sécrétion inappropriée de vasopressine, la cirrhose du foie, le syndrome néphrotique, le trouble obsessionnel compulsif, l'anxiété et les troubles dépressifs, ainsi que les méthodes de synthèse desdits composés.

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