Indol-3-yl-carbonyl-piperidin and piperazin derivatives

Details Indol-3-yl-carbonyl-piperidin and piperazin derivatives Indol-3-yl-carbonyl-piperidin and piperazin derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/454 (2006.01) A61P 9/12 (2006.01) C07D 209/22 (2006.01) C07D 209/42 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2616937

The present invention relates to indol-3-yl-carbonyl-piperidin and piperazin derivatives which act as V1a receptor antagonists and which are represented by Formula (I) wherein the residues R1 to R3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, their use in medicaments against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders, and methods of preparation thereof.

Cette invention concerne des dérivés de indol-3-yl-carbonyl-pipéridine et pipérazine qui servent d'antagonistes des récepteurs V1a et qui sont représentés par la formule (I), dans laquelle les restes R1 à R3 sont définis dans les pièces descriptives de la demande. Cette invention concerne en outre des compositions pharmaceutiques contenant ces composés, leur utilisation dans des médicaments contre la dysménorrhée, l'hypertension, l'insuffisance cardiaque chronique, la sécrétion inappropriée de vasopressine, la cirrhose du foie, le syndrome néphrotique, les troubles obsessionnels compulsifs et les troubles de l'anxiété et de la dépression, ainsi que des procédés de préparation de ceux-ci.

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