C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/08 (2006.01) A61K 31/404 (2006.01) A61P 25/24 (2006.01)
Patent
CA 2390531
This invention provides novel compounds and pharmaceutical compositions and methods of using the compounds in the treatment of central nervous system disorders, such as anxiety and depression, the compounds having formula (I), wherein: X is N-R, O, S(O)m; m is 0 to 2; n is 0 to 4; Ar is an aryl group of 6 to 12 carbon atoms optionally substituted with 1 to 3 R3 groups, or a heteroaryl group of 4 to 10 carbon atoms optionally substituted with 1 to 3 R3 groups; R and R2 are independently H, straight chain alkyl of 1 to 6 carbon atoms, branched alkyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, alkoxycarbonyl of 1 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon atoms, aminocarbonyl, or alkylaminocarbonyl of 1 to 4 carbon atoms; R1 and R3 are independently H, straight chain alkyl of 1 to 4 carbon atoms, branched alkyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, halo, alkoxy group of 1 to 4 carbon atoms, haloalkyl of 1 to 4 carbon atoms, OH, nitro, amino, sulfonyl, CN, carboxy, alkoxycarbonyl of 1 to 4 carbon atoms, alkylcarbonyl of 1 to 4 carbon atoms, aminocarbonyl, or alkylaminocarbonyl of 1 to 4 carbon atoms; and all crystalline forms or a pharmaceutically acceptable salt thereof.
La présente invention concerne des composés, des compositions pharmaceutiques ainsi que toutes leurs formes cristallines ou l'un de leurs sels pharmaceutiquement acceptables et des modalités d'utilisation de ces composés pour le traitement de troubles du système nerveux central tels que l'anxiété et la dépression. Ces composés sont représentés par la formule générale (I). Dans cette formule, X est N-R, O, S(O)¿m?; m vaut 0 à 2; n vaut 0 à 4. Ar est un groupe aryle en C¿6?-C¿12? éventuellement substitué par 1 à 3 groupes R¿3?, ou un groupe hérétoaryle en C¿4?-C¿10? éventuellement substitué par 1 à 3 groupes R¿3?. R et R¿2? sont indépendamment H, chaîne alkyle droite en C¿1?-C¿6?, alkyle ramifié en C¿3?-C¿6?, cycloalkyle en C¿3?-C¿6?, alcoxycarbonyle en C¿1?-C¿6?, alkylcarbonyle en C¿1?-C¿6?, aminocarbonyle, ou alkylaminocarbonyle en C¿1?-C¿4?. R¿1? et R¿3? sont indépendamment H, chaîne alkyle droite en C¿1?-C¿4?, alkyle ramifié en C¿3?-C¿6?, cycloalkyle en C¿3?-C¿8?, halo, groupe alcoxy en C¿1?-C¿4?, haloalkyle en C¿1?-C¿4?, OH, nitro, amino, sulfonyle, CN, carboxy, alkoxycarbonyle en C¿1?-C¿4?, alkylcarbonyle en C¿1?-C¿4?, aminocarbonyle, ou alkylaminocarbonyle en C¿1?-C¿4?.
Asselin Magda
Ellingboe John Watson
Mewshaw Richard Eric
Ridout & Maybee Llp
Wyeth
LandOfFree
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