A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/405 (2006.01)
Patent
CA 2321455
The cytotoxic effects of amyloid beta protein on cells are prevented by contacting the cells with an effective amount of an indole-3-propionic acid or a salt or ester thereof. Furthermore, a fibrillogenic disease can be treated in a human subject by administering to the human subject an amount of an indole-3-propionic acid or a salt or ester thereof effective to prevent or reverse fibrillogenesis. Oxidation in a biological sample can be decreased by contacting the biological sample with an effective amount of an indole-3-propionic acid or a salt or ester thereof. Additionally, diseases or other conditions where free radicals and/or oxidative stress play a role can be treated by administering an effective amount of an indole-3-propionic acid or a salt or ester thereof.
On évite les effets cytotoxiques de la protéine bêta amyloïde sur des cellules en mettant ces dernières en contact avec une dose efficace d'acide indole-3-propionique ou d'un sel ou d'un ester dudit acide. De plus, il est possible de traiter une maladie fibrillogène chez un humain en lui administrant une dose d'acide indole-3-propionique ou d'un sel ou d'un ester dudit acide, efficace pour prévenir ou traiter la fibrillogenèse. On peut atténuer l'oxydation d'un échantillon biologique en mettant ledit échantillon en contact avec une dose efficace d'acide indole-3-proprionique ou d'un sel ou d'un ester dudit acide. Il est également possible de traiter diverses pathologies dans lesquelles interviennent des radicaux libres et/ou un stress oxydatif par administration d'une dose efficace d'acide indole-3-proprionique ou d'un sel ou d'un ester dudit acide.
Frangione Blas
Ghiso Jorge
Pappolla Miguel A.
Poeggeler Burkhard
Borden Ladner Gervais Llp
New York University
South Alabama Medical Science Foundation
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