Indole amide derivatives as ep4 receptor antagonists

Details Indole amide derivatives as ep4 receptor antagonists Indole amide derivatives as ep4 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/404 (2006.01) A61K 31/416 (2006.01) A61K 31/4184 (2006.01) A61K 31/4192 (2006.01) C07D 209/12 (2006.01) C07D 209/30 (2006.01) C07D 231/56 (2006.01) C07D 235/06 (2006.01) C07D 249/18 (2006.01)

Patent

CA 2648729

The invention is directed to indole amide derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer. Pharmaceutical compositions and methods of use are also included.

L'invention concerne des dérivés d'indolamide comme antagonistes du récepteur EP4 qui sont utiles pour le traitement de maladies ou affections médiées par l'EP4, par exemple la douleur aiguë et chronique, l'ostéoarthrite, la polyarthrite rhumatoïde et le cancer. L'invention concerne également des compositions pharmaceutiques ainsi que des procédés d'utilisation.

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