C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 411/14 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2297825
The present invention relates to indole and 2,3-dihydroindole derivatives having formula (I) any of its enantiometers or any mixture thereof, or an acid addition salt thereof, wherein A, R1, R2, R3, W, X, Y and Z are as described in the description. The compounds are potent serotonin reuptake inhibitors and have 5-HT1A receptor antagonistic activity.
La présente invention concerne des dérivés indole et 2,3-dihydro-indole, correspondant à la formule (I), tout énantiomère ou mélange de ceux-ci, ou un sel d'addition d'acide de ces dérivés. Dans cette formule A, R<1>, R<2>, R<3>, W, X, Y et Z sont tels que dans la description. Ces composés constituent de puissants inhibiteurs de réabsorption de la sérotonine et possèdent une activité antagoniste à l'égard du récepteur de 5-HT1A.
Mikkelsen Ivan
Moltzen Ejner Knud
Perregaard Jens Kristian
Smith Garrick Paul
H. Lundbeck A/s
Robic
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