Indole and azaindole derivatives with antitumor action

A - Human Necessities – 61 – K

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A61K 31/00 (2006.01) A61K 31/282 (2006.01) A61K 31/337 (2006.01) A61K 31/404 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2564249

Indole and azaindole compounds useful for the treatment of solid tumours and tumours of the blood are described, they being particularly effective in the treatment of drug resistant tumours; these compounds are also able to synergistically enhance the activity of known antitumour drugs. They can hence be used either alone as antitumour agents or in association with known antitumour drugs. Processes for preparing the aforesaid compounds, which are partly new, and pharmaceutical compositions useful for the aforesaid treatments are also described.

L'invention concerne des composés d'indole et d'azaindole utiles pour traiter des tumeurs solides et des tumeurs sanguines. Ces dérivés sont particulièrement efficaces pour traiter des tumeurs résistant aux médicaments. Ces composés permettent également d'accroître synergétiquement l'activité de médicaments antitumoraux connus. Par conséquent, ils peuvent être utilisés soit seuls, soit en tant qu'agents antitumoraux, ou associés à des médicaments antitumoraux connus. Des procédés pour préparer les composés susmentionnés, qui sont partiellement nouveaux, et des compositions pharmaceutiques utiles pour les traitements susmentionnés sont également décrits dans la description.

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