C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/439 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2679866
The use of substituted amides of structure (I) for modulating the activity of 11 .beta.-hydroxysteroid dehydrogenase type 1 (11 .beta.HSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11 .beta.HSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.
L'invention porte sur l'utilisation d'amides substitués de structure (I) pour moduler l'activité de la 11.beta.-hydroxystéroïde déshydrogénase de type 1 (11 .beta.HSD1) et sur l'utilisation de ces composés comme compositions pharmaceutiques. L'invention porte également sur une nouvelle classe d'amides substitués, sur leur utilisation en thérapie, sur des compositions pharmaceutiques comprenant les composés, ainsi que leur utilisation dans la fabrication de médicaments. Les présents composés sont des modulateurs et, plus spécifiquement, des inhibiteurs de l'activité de 11 .beta.HSD1 et peuvent être utiles dans le traitement, la prévention et/ou la prophylaxie d'une gamme de troubles médicaux où une concentration intracellulaire diminuée de glucocorticoïde actif et souhaitable.
Andersen Henrik Sune
Kampen Gita Camilla Tejlgaard
Kilburn John Paul
High Point Pharmaceuticals Llc
Smart & Biggar
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