Indole/benzimidazole compounds as mtor kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 403/04 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2752527

The present invention provides compounds that are kinase inhibitors, specifically PIK kinase inhibitors, more specifically, mTOR inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of kinases, specifically PIK kinase inhibitors, more specifically, mTOR such as cancer. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

La présente invention concerne des composés qui sont des inhibiteurs de kinases, en particulier des inhibiteurs de kinases PIK, et plus particulièrement des inhibiteurs de mTOR, ce qui fait qu'il conviennent pour le traitement d'affections, telles que le cancer, pouvant se traiter par inhibition de kinases, en particulier au moyen d'inhibiteurs de kinases PIK, et plus particulièrement des inhibiteurs de mTOR. L'invention concerne également, d'une part des compositions pharmaceutiques contenant de tels composés, et d'autre part des procédés d'élaboration de tels composés.

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