Indole, benzofuran,and benzothiophene containing...

Details Indole, benzofuran,and benzothiophene containing... Indole, benzofuran,and benzothiophene containing...

C - Chemistry, Metallurgy

07

D

C07D 333/66 (2006.01) A61K 31/38 (2006.01) A61K 38/03 (2006.01) C07D 209/14 (2006.01) C07D 307/81 (2006.01) C07D 307/82 (2006.01) C07D 333/58 (2006.01) C07F 7/10 (2006.01) C07K 4/00 (2006.01)

Patent

CA 2024672

Pro-drugs of potent 5-lipoxygenase inhibiting compounds comprise compounds of the formula (See formula I) in which A is an alkylene or allcenylene group, X is oxygen, sulfur, sulfoxyl, or substituted nitrogen, and Y is a group which includes substituted or unsubstituted carbocyclic or substituted or unsubstituted heterocyclic aryl. R1 is an alkyl, alkenyl, amino, alkylamino, dialkylamino, or hydroxyamino group or an amine group bearing a metabolically cleavable leaving group. M is hydrogen, a pharmaceutically acceptable cation or a metabolically cleavable leaving group, with the proviso that either M or R1 must bear a metabolically cleavable leaving group.

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