Indole compound and use thereof

Details Indole compound and use thereof Indole compound and use thereof

C - Chemistry, Metallurgy

07

D

C07D 209/18 (2006.01) A61K 31/404 (2006.01) A61K 31/405 (2006.01) A61K 31/41 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/4709 (2006.01) A61K 45/00 (2006.01) A61P 9/04 (2006.01) A61P 9/06 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 11/08 (2006.01) A61P 11/10 (2006.01) A61P 11/14 (2006.01) A61P 15/00 (2006.01) A61P 27/16 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 209/22 (2006.01) C07D 209/26 (2006.01) C

Patent

CA 2599348

A compound represented by the general formula (I) or a salt or solvate thereof or a prodrug thereof. The compound or the salt or solvate thereof or the prodrug thereof has a leukotriene receptor antagonistic effect which is expected to be more effective than those of the leulotriene receptor antagonists currently used in clinical medicine and, therefore, is useful as an agent for prevention and/or treatment of a leukotriene-mediated disease such as a respiratory disease (e.g., bronchial asthma, chronic obstructive pulmonary disease, pulmonary emphysema, chronic bronchitis, pneumonia (e.g., interstitial pneumonia), severe acute respiratory syndrome (SARS), acute respiratory distress syndrome (ARDS), allergic rhinitis, sinusitis (e.g., acute sinusitis, chronic sinusitis) or the like, an expectorant or an antitussive. (I) wherein all of the symbols are as defined in the description.

L~invention concerne un composé représenté par la formule générale (I) ou un sel ou un solvate de celui-ci ou bien un médicament dérivé de celui-ci. Le composé ou le sel ou solvate de celui-ci ou le médicament dérivé de celui-ci exerce un effet antagoniste de récepteur leukotriène qui devrait être plus efficace qu~avec les antagonistes de récepteur leukotriène utilisés couramment dans la médecine clinique et se révèle donc utile comme agent de prévention et/ou de traitement d~une maladie induite par leukotriène comme une maladie respiratoire (par exemple asthme bronchial, bronchopneumopathie chronique obstructive, emphysème pulmonaire, bronchite chronique, pneumonie (par exemple pneumonie interstitielle), syndrome respiratoire aigu sévère (SRAS), syndrome de déficience respiratoire aiguë (SDRA), rhinite allergique, sinusite (par exemple sinusite aiguë, sinusite chronique) ou équivalent, expectorant ou antitussif. (I) où tous les symboles sont tels que définis dans la description.

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