Indole derivative and drug containing the same

Details Indole derivative and drug containing the same Indole derivative and drug containing the same

C - Chemistry, Metallurgy

07

D

C07D 209/12 (2006.01) A61K 31/404 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2490878

An indole derivative represented by the following general formula (1) : (see formula 1) wherein at least one of R1, R2, R3, and R 4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents -(CH2)n OH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component. The indole derivative (1) of the present invention has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.

La présente invention se rapporte à un dérivé d'indole représenté par la formule générale suivante (1) ou à son sel ainsi qu'à un médicament et à un promoteur de différenciation des cellules souches contenant ledit dérivé en tant qu'ingrédient actif. Dans la formule (1), l'un au moins des groupes R?1¿, R?2¿, R?3¿ et R?4¿ représente alcoxy C¿1-20?, les autres groupes représentent hydrogène, alky C¿1-6?, acétyle ou hydroxy ; et soit X soit Y représente -(CH¿2?)¿n?OH (où n est compris entre 0 et 30) tandis que l'autre représente hydrogène. Le dérivé d'indole (1) mentionné ci-dessus, qui possède un effet d'induction de la différenciation des cellules souches nerveuses spécifiquement en cellules nerveuses, est utile en tant que médicament destiné à la prévention et au traitement des neuropathies.

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