Indole derivative for the treatment of migraine

Details Indole derivative for the treatment of migraine Indole derivative for the treatment of migraine

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01)

Patent

CA 2213241

This invention relates to (R)-5- (Aminosulphonylmethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H- indole of formula I and its pharmaceutically acceptable salts. This compound is particularly useful in treating disorders arising from deficient serotonergic neurotransmission, especially migraine. Image

On décrit un composé (R)-5-(aminosulfonylméthyl)-3-(N-méthylpyrrolidin-2-ylméthyl)-1H-indole ainsi que les sels de celui-ci, acceptables sur le plan pharmacologique. Ce composé est particulièrement utile dans le traitement de troubles survenant à la suite d'une neurotransmission sérotoninergique déficiente, tels que notamment la migraine.

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