Indole derivative having piperidine ring

Details Indole derivative having piperidine ring Indole derivative having piperidine ring

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/454 (2006.01) C07D 401/04 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2564062

Compounds represented by the general formula (I) or pharmacologically acceptable salts thereof; and use of the same as drugs: [wherein R1 and R2 are adjacent substituents and R1 and R2 together with the two carbon atoms to which they are bonded respectively form a 5- to 7-membered nonaromatic hydrocarbon ring which may have one to four substituents selected from among (1) oxo, (2) hydroxyl, an so on; R3 is hydrogen or the like; and R6 is hydrogen or the like]. The compounds exhibit the ability to combine with 5- HT1A receptor and 5-HT1A receptor antagonism and are useful as therapeutic or preventive agents for lower urinary tract symptoms, particularly urine accumulation symptom.

Composés représentés par la formule générale (I) ou sels acceptables du point de vue pharmacologique de ceux-ci ; et utilisation de ceux-ci comme médicaments : (I) [dans laquelle R<1> et R<2> sont des substituants adjacents et R<1> et R<2> ainsi que les deux atomes de carbone auxquels ils sont liés respectivement forment un cycle hydrocarboné non aromatique ayant 5 à 7 éléments lequel peut avoir un à quatre substituants choisis parmi (1) un oxo, (2) un hydroxyle et ainsi de suite ; R<3> est un hydrogène ou similaire ; et R<6> est un hydrogène ou similaire]. Les composés présentent l'aptitude à se combiner au récepteur 5-HT1A et un antagonisme vis-à-vis du récepteur 5-HT1A et sont utiles comme agents thérapeutiques ou préventifs pour des symptômes du tractus urinaire inférieur, en particulier pour le symptôme d'accumulation d'urine.

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