C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/319, 260/306
C07D 209/14 (2006.01) C07D 209/16 (2006.01) C07D 209/18 (2006.01) C07D 209/48 (2006.01) C07D 403/06 (2006.01)
Patent
CA 1169428
ABSTRACT Compounds are disclosed of general formula Image (I) wherein R1, R3, R4, R6 and R7, which may be the same or different, each represents a hydrogen atom or an alkyl group; R2 represents a hydrogen atom or an alkyl, aryl, aralkyl, cycloalkyl or alkenyl qroup; or R1 and R2, together with the nitrogen atom to which they are attached, form a saturated monocyclic 5 to 7-membered ring which may optionally contain a further hetero function; R5 represents a hydrogen atom or an alkyl or alkenyl group; or R4 and R5 together form an aralkylidene group; Alk represents an alkylene chain containing two or three carbon atoms which may be unsubstituted or substituted by not more than two C1-3 alkyl groups; and X represents an oxygen or sulphur atom; and physiologically acceptable salts, solvates and bioprecursors thereof. The compounds are described as potentially useful for the treatment of migraine and may be formulated as pharmaceutical compositions in conventional manner using one or more pharmaceut- ically acceptable carriers or excipients. Various processes for the preparation of the compounds are disclosed including, for example, a process involving reacting an indole having an appropriate nitrile group at the 5-position, with a suitable oxygen- or sulphur-containing compound in order to introduce the required amide or thioamide group at the 5- position on the indole nucleus.
383670
Bays David E.
Dowle Michael D.
Webb Colin F.
Glaxo Group Limited
Riches Mckenzie & Herbert Llp
LandOfFree
Indole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Indole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indole derivatives will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1191139