Indole derivatives

Details Indole derivatives Indole derivatives

C - Chemistry, Metallurgy

07

D

C07D 209/60 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2084442

RAN 4083/015 Abstract cis-2,3,3a,4,5,9b-Hexahydro-1H-benzo[b]indole derivatives of the general formula Image I wherein R1 signifies a residue of the formula -O-CO-NR4R5, R2 signifies lower alkyl, lower cycloalkyl or lower alkyl substituted by lower cyclvalkyl, aryl, aroyl, aroylamino, amino or by a cyclic amino, amide or imide group, R3 signifies hydrogen or lower alkyl, R4 signifies lower alkyl and R5 signifies hydrogen or lower alkyl, corresponding trans isomers or cis-trans isomer mixtures and pharmaceutically usable salts thereof are novel and are distinguished by valuable therapeutic properties. They are especially suitable for the treatment or prophylaxis of cognitive disorders and senile dementia (especially Alzheimer's disease) and for the improvement of memory capacity.

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