Indole derivatives

Details Indole derivatives Indole derivatives

C - Chemistry, Metallurgy

07

D

260/279, 260/278

C07D 401/06 (2006.01) C07D 209/14 (2006.01) C07D 211/56 (2006.01)

Patent

CA 1041512

ABSTRACT The invention provides processes for preparing compounds of general formula I Image I and acid addition and quaternary ammonium salts thereof, wherein R represents hydrogen or lower alkyl, R1 represents hydrogen, lower alkyl, aryl lower alkyl or aroyl, R2 represents hydrogen, lower alkyl, or aryl, R3 represents hydrogen, halogen, lower alkoxy, aryl lower alkoxy, hydroxy, or lower alkyl, R4 represents hydrogen, lower alkyl, cyclo- alkyl or 5 to 7 carbon atoms, aryl lower alkyl, aryl (including heterocyclic aryl), or acyl. A represents an alkylene, mono-or dik?to- or hydroxy-alkylene radical having form 1 to 5 carbon atoms and x is oxygen or sulphur. The compounds exhibit action on the cardiovascular system particularly hypotensive and/or anti-hypertensive activity.

210138

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