Indole derivatives

Details Indole derivatives Indole derivatives

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2062587

ABSTRACT The present invention provides Indole derivatives represented by the formula (I) Image (I) wherein R1, R2 and R3 independently represent hydrogen or lower alkyl; R4 represents hydrogen, lower alkyl or cycloalkyl; R5 represents hydrogen, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, -CHR7R8 where R7 and R8 independently represent hydrogen, alkyl, alkenyl, alkynyl, substituted or unsubstituted cycloalkyl, -(CH2)mOR9 (wherein m is an integer of 1 - 3 and R9 is lower alkyl), substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, or substituted or unsubstituted thienyl], Image (wherein p is an integer of 1 - 3) or Image (wherein Y is CH2, O, S, CH2-CH2, CH=CH, CH2-CO or CH2-S); R6 represents hydrogen, lower alkyl or lower alkoxy or halogen; X represents O or S(O)q (wherein q is an integer of 0-2); and n represents an integer of 1-6} or pharmaceutically acceptable salts thereof. The compound shows prominent inhibition effects on steroid 5.alpha.-reductase activity, and are useful in treating benign prostatic hypertrophy, prostate cancer, baldness and acne.

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