Indole derivatives

Details Indole derivatives Indole derivatives

C - Chemistry, Metallurgy

07

D

167/208, 260/279

C07D 401/12 (2006.01) A61K 31/395 (2006.01) C07D 209/42 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2030051

Disclosed are compounds of formula I (See formula I) wherein R1 is a hydrogen atom, a C1-C6 alkyl group, benzyl or an indolyl carbonyl group, R2 is a saturated or unsaturated 5- to 8-membered heterocyclic group containing as a hetero atom one or more nitrogen atoms, the heterocyclic group is optionally substituted at an N or C atom by a C1-C6 alkyl or aralkyl group, n is an integer of 1 to 5 and one or more hydrogen atoms, in an alkylene chain -(CH2)n- are optionally substituted by a C1-C6 alkyl, phenyl, benzyl and/or hydroxyl group, physiologically acceptable salts and quaternary ammonium salts thereof. The compounds are selective antagonists of 5-HT3 receptors and are useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.

Affiliated with

Also associated with

Rating

Indole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Indole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indole derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1921369