Indole derivatives and medical applications thereof

Details Indole derivatives and medical applications thereof Indole derivatives and medical applications thereof

C - Chemistry, Metallurgy

07

D

C07D 491/22 (2006.01) A61K 31/485 (2006.01) A61P 11/14 (2006.01) A61P 25/04 (2006.01) A61P 25/28 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2427931

Indole derivatives represented by the general formula (I) or pharmacologically acceptable salts thereof, and pharmaceutical compositions (particularly d opioid receptor agonist) containing the same: (I) wherein R1 is hydrogen, C1-5 alkyl, or the like; R2 is hydrogen, hydroxyl, or the like; R3 is hydrogen, hydroxyl, or the like; -Z- is a bridge having 2 to 5 carbon atoms; m is an integer of 0 to 3; n is an integer of 0 to 10; R4 and R5 are each fluoro, hydroxyl, or the like; R9 is hydrogen, C1-5 alkyl, or the like; and R10 and R11 may be united to form O- or the like.

L'invention concerne des dérivés d'indole représentés par la formule générale (I) dans laquelle R?1¿ représente hydrogène, alkyle C¿1-5? ou analogues ; R?2¿ représente hydrogène, hydroxyle ou analogues ; R?3¿ représente hydrogène, hydroxyle ou analogues ; Z représente un pont contenant de 2 à 5 atomes de carbone ; m représente un entier de 0 à 3 ; n représente un entier de 0 à 10 ; R?4 ¿et R?5¿ représentent chacun fluoro, hydroxyle ou analogues ; R?9¿ représente hydrogène, alkyle C¿1-5? ou analogues ; et R?10 ¿et R?11¿ peuvent être unis pour former O ou analogues. L'invention concerne également les sels pharmaceutiquement acceptables desdits dérivés ainsi que des compositions pharmaceutiques (notamment un agoniste du récepteur opioïde .delta.) contenant lesdits dérivés ou sels.

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