Indole derivatives and processes for preparation thereof

Details Indole derivatives and processes for preparation thereof Indole derivatives and processes for preparation thereof

C - Chemistry, Metallurgy

07

D

167/230, 260/207

C07D 451/02 (2006.01) A61K 31/46 (2006.01)

Patent

CA 2017621

ABSTRACT The invention relates to novel indole derivatives having the general formula: Image wherein R1 is lower alkyl and R2 and R3 are each hydrogen, lower alkyl or linked together to form a bond; or R1 and R2 are linked together to form lower alkylene, and R3 is hydrogen, and R4 is azabicyclo(C5- C12)alkyl(lower)alkyl or its N-oxide, each of which may be substituted by lower alkyl, provided that R4 is N- oxide of azabicyclo(C5-C12)alkyl(lower)alkyl, which may be substituted by lower alkyl when R1 is lower alkyl and R2 and R3 are each hydrogen or lower alkyl, and their pharmaceutically acceptable salts. The indole derivatives of the invention are useful as a potent and selective antagonist of 5-HT receptor.

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