Indole derivatives and their use as thyroid receptor ligands

Details Indole derivatives and their use as thyroid receptor ligands Indole derivatives and their use as thyroid receptor ligands

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/404 (2006.01) A61P 5/14 (2006.01) C07D 209/18 (2006.01) C07D 209/20 (2006.01) C07D 405/04 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2651134

The invention provides compounds of formula (I) or pharmaceutically acceptable esters, amides, solvates or salts thereof, including salts of such esters or amides, and solvates of such esters, amides or salts, (I) wherein R1, R2, R3, R4, R5, R6, Y and W are as defined in the specification. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition that may be treated with a thyroid receptor agonist or partial agonist.

L'invention concerne des composés représentés par la formule (I), ou des esters, amides, solvates ou sels pharmaceutiquement acceptables desdits composés, y compris des sels desdits esters ou amides, et des solvates desdits esters, amides ou sels. Dans ladite formule (I), R1, R2, R3, R4, R5, R6, Y et W sont tels que définis dans la description. L'invention concerne également l'utilisation desdits composés dans le traitement ou la prophylaxie d'une pathologie pouvant être traitée à l'aide d'un agoniste ou d'un agoniste partiel des récepteurs thyroïdiens.

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