Indole derivatives as 5-ht1 agonists

Details Indole derivatives as 5-ht1 agonists Indole derivatives as 5-ht1 agonists

C - Chemistry, Metallurgy

07

D

C07D 403/02 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) C07C 271/24 (2006.01) C07D 209/14 (2006.01) C07D 209/48 (2006.01) C07D 401/02 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 413/02 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 417/02 (2006.01)

Patent

CA 2181475

Compounds of formula (I) wherein R and R1 are hydrogen, C1-4 alkyl or are linked to form a ring, A is a cycloalkyl or alkyl-cycloalkyl group, n is an integer from 0 to 3, W is an optionally substituted 5-or 6-membered heterocyclic ring; or W is an optionally substituted aryl, heteroaryl, aryloxy or thiophenoxy group; or W is a group -SO2NR6R7 -NHC(O)R6R7 or -C(O)NHR6R7; are useful in treating clinical conditions for which a "5-HT1-like" receptor agonist is indicated.

Composés selon la formule (I), dans lesquels R et R?1¿ sont l'hydrogène, un alkyle C¿1-4? ou sont liés de façon à former un cycle, A est un cycloalkyle ou un groupe alkyle-cycloalkyle, n est un nombre entier compris entre 0 et 3, W est un hétérocycle à 5 ou 6 éléments avec substitution éventuelle, ou un groupe aryle, hétéroaryle, aryloxy ou thiophénoxy avec substitution éventuelle, ou un groupe -SO¿2?NR?6¿R?7¿ -NHC(O)R?6¿R?7¿ ou -C(O)NHR?6¿R?7¿. Ces composés sont utiles pour le traitement d'états cliniques pour lesquels il est indiqué d'utiliser un agoniste des récepteurs de type 5-HT¿1?.

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