Indole derivatives as tyrosine kinase inhibitors

Details Indole derivatives as tyrosine kinase inhibitors Indole derivatives as tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/495 (2006.01) A61K 45/06 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2387351

The present invention relates to compounds of Formula I which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals. (see formula I)

La présente invention se rapporte à des composés qui inhibent, régulent et/ou modulent la transduction des signaux de tyrosine kinases, à des compositions qui contiennent ces composés et à des procédés d'utilisation de ces composés pour traiter des maladies et des troubles dépendant des tyrosine kinases, tels que l'angiogenèse, le cancer, la croissance tumorale, l'athérosclérose, la dégénérescence maculaire liée à l'âge, la rétinopathie diabétique, des maladies inflammatoires et analogues, chez des sujets mammifères.

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