A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61P 19/02 (2006.01) A61P 19/04 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2550105
This invention relates to a method for preventing and/or treating bone diseases which comprises administering a potentiator of TGF-beta activity such as the compound of the formula [I] or pharmaceutically acceptable salts thereof to human being or animals. wherein R1 is hydrogen, etc., R2 is optionally substituted ar(lower)alkyl or optionally substituted heterocyclic(lower)alkyl, etc., R3 is hydrogen, optionally substituted hydroxy, etc., R4 is hydrogen or lower alkyl, and X is CH or N.
L'invention concerne se rapporte à une méthode de prévention et/ou de traitement de maladies des os, qui consiste à administrer un potentialisateur de l'activité TGF-bêta, tel que le composé représenté par la formule (I), ou des sels pharmaceutiquement acceptables de ce composé, à des êtres humains ou des animaux. Dans la formule (I), R<sp>1 </sp>est hydrogène, etc., R<sp>2</sp> est aralkyle (inférieur) éventuellement substitué ou alkyle (inférieur) hétérocyclique éventuellement substitué, etc., R<sp>3</sp> est hydrogène, hydroxy éventuellement substitué, etc., R<sp>4</sp> est hydrogène ou alkyle inférieur, et X est CH ou N.
Inoue Takayuki
Takeshita Nobuaki
Astellas Pharma Inc.
Dennison Associates
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