Indole derivatives for treating neurodegenerative diseases

Details Indole derivatives for treating neurodegenerative diseases Indole derivatives for treating neurodegenerative diseases

C - Chemistry, Metallurgy

07

D

C07D 209/16 (2006.01) A61K 31/4045 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2754283

The invention relates to a compound of the following formula (I), or to a pharmaceutically acceptable salt thereof or to a stereoisomer or mixture of stereoisomers at any proportions, where: X1 is a CH2 or C=O group; X2 is a linear saturated or unsaturated carbohydrate chain with 8 to 24 carbon atoms; R1 is a hydrogen atom or an OH or (C1-C6)alkoxy group such as methoxy; and R2 is a CH3 or CH2OR3 group, with R3 being a hydrogen atom or a (C1-C6)alkyl, CO-(C1-C6)alkyl or NH-(C1-C6)alkyl group. The invention also relates to the use of said compound as a drug, in particular for treating neurodegenerative diseases, and to a method for preparing same.

La présente invention concerne un composé de formule (I) suivante : ou un sel pharmaceutiquement acceptable de celui-ci, un stéréoisomère ou un mélange de stéréoisomères en toutes proportions, dans laquelle: - X1 représente un groupe CH2 ou C=O, - X2 représente une chaîne hydrocarbonée linéaire, saturée ou insaturée, comportant 8 à 24 atomes de carbone, - R1 représente un atome d'hydrogène ou un groupe OH ou (C1-C6)alcoxy, tel que méthoxy, et - R2 représente un groupe CH3 ou CH2OR3, avec R3 représentant un atome d'hydrogène ou un groupe (C1-C6)alkyle, CO-(C1-C6)alkyle ou NH-(C1-C6)alkyle, ainsi que son utilisation en tant que médicament, notamment pour le traitement de maladies neurodégénératives, et son procédé de préparation.

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