Indole derivatives, pharmaceutical compositions and methods...

Details Indole derivatives, pharmaceutical compositions and methods... Indole derivatives, pharmaceutical compositions and methods...

C - Chemistry, Metallurgy

07

D

C07D 209/20 (2006.01) A61K 31/405 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 209/18 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 413/06 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2090240

2090240 9300334 PCTABS00019 A compound having formula (I), wherein R1 and R2 independently are selected from the group consisting of H, C3-C12 straight or branched alkyl, aryl or lower alkyl-substituted aryl; or R1 and R2 may be joined to form a 4- to 6-membered saturated or unsaturated ring or a 4- to 6-membered saturated or unsaturated lower alkyl-substituted ring; R3 is H, C1-C12 straight or branched alkyl, NO2, NH2, N3, CN, halogen, CO2R, OR, or SR wherein R is H or lower alkyl; R4 is H, C1-C12 straight or branched alkyl, NO2, NH2, N3, CN, halogen, CO2R, OR, or SR wherein R is H or lower alkyl; A is nothing or a C1-C5 alkylene to form a ring; Z is O, NH, S, or -CH=CH-; and n is an integer of 1-3; or a pharmaceutically acceptable salt thereof. The compounds are useful in compositions and methods for treating psychiatric and neurological disorders.

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