Indole derivatives, preparation processes and medicinal...

Details Indole derivatives, preparation processes and medicinal... Indole derivatives, preparation processes and medicinal...

C - Chemistry, Metallurgy

07

D

C07D 209/18 (2006.01) C07D 209/14 (2006.01) C07D 209/16 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2063170

NEW INDOLE DERIRATIVES, PREPARATION PROCESSES AND MEDICINAL PRODUCTS CONTAINING THEM Abstract The invention relates to indole derivatives of formula 1, Image in which: R1 and R2 represent H, alkyl, alkenyl, cycloalkyl, N alkylamino- or N,N-dialkylaminoalkyl, benzyl, pyridyl- methyl or phenyl, optionally substituted, R3 and R4 represent H, halogen, alkyl, alkoxy, alkylthio, CF3, NO2, N-alkylamino or N,N-dialkylamino, benzyl or phenyl, optionally substituted, R5 represents H, alkyl, cycloalkyl or optionally substituted benzyl, R6 denotes an alkyl, phenyl or heterocyclic radical, optionally substituted, Z denotes the bivalent radicals -(CH2)n-C(R7R8)-(CH2)p-, -CH=CH-C(R7R8)- in which n=0-2, p=0-2 and n+p?2, R7 and R8 represent H, alkyl, alkenyl, cycloalkyl, N-alkylamino, N,N-dialkylamino, N-alkylamino- or N,N-dialkylaminoalkyl, benzyl or phenyl, where appropriate substituted, or together form polymethylene or oxa-, thia- or - 2 - azapolymethylene chains, as well as their tautomeric forms, to processes for preparing them and to their application as hypo- lipidaemic, antiatheromatous and antidiabetic pharmaceutical products.

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