C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/279, 260/319
C07D 209/04 (2006.01) C07C 205/37 (2006.01) C07D 209/08 (2006.01) C07D 209/42 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 1202972
ABSTRACT Novel indole derivatives, processes for their manufacture and their use as medicaments Novel indole derivatives of the general formula I Image (I) (in which R1 represents H, C1-C6-alkyl or benzyl, R2 represents H, C1-C4-alkyl, free or esterified C1-C4- hydroxyalkyl or free, amidated or esterified COOH or carboxyalkyl, R3 represents H or C1-C6-alkyl, R4 repre- sents H or C1-C6-alkyl and R5 represents H, C1-C6-alkyl, alkenyl, cycloalkyl or cycloalkyl-alkyl optionally sub- stituted by free, amidated or esterified COOH or by -76- optionally substituted phenyl, or C2-C8-di- or poly- methylene attached to another indole group) and physiologically tolerable salts with acids thereof and alkali and alkaline earth metal salts of such COOH- compounds, and processes for the manufacture thereof. The aforesaid novel compounds have .beta.-receptor stimulating activity and also an anti-allergic, anti- phlogistic and analgesic activity and accordingly may be made up with suitable carriers into pharmaceutical preparations.
400813
Heindl Josef
Loge Olaf
Marks & Clerk
Schering Aktiengesellschaft
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