Indole derivatives useful as endothelin receptor antagonist

Details Indole derivatives useful as endothelin receptor antagonist Indole derivatives useful as endothelin receptor antagonist

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/36 (2006.01) A61K 31/405 (2006.01)

Patent

CA 2308478

The invention provides S-(+)-3-{1-(1,3-benzodioxol- 5-yl)-2-[(2-methoxy-4-methylphenyl)sulfonylamino]-2- oxoethyl)-1-methyl-1H-indole-6-carboxylic acid, represented by the following formula: (see formula I) which is substantially free from its (R)-(-)enantiomer, and pharmaceutically acceptable derivatives thereof. The compound is useful in the treatment of inter alia acute renal failure, restenosis and pulmonary hypertension.

L'invention concerne un acide S-(+)-3-{ 1,3-benzodioxol -5-yl)-2-[ (2-méthoxy-4- méthylphényl)sulfonylamino] -2-oxoéthyl }-1-méthyl -1H-indole- 6 carboxylique représenté par la formule (a) qui est sensiblement exempt de son (R)-(-)-énantiomère et ses dérivés pharmaceutiquement acceptables. Les composés sont utiles dans le traitement notamment d'insuffisance rénale aiguë, de resténose et d'hypertension pulmonaire.

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