Indole derivatives useful as progesterone receptor modulators

Details Indole derivatives useful as progesterone receptor modulators Indole derivatives useful as progesterone receptor modulators

C - Chemistry, Metallurgy

07

D

C07D 209/30 (2006.01) A61K 31/404 (2006.01) A61P 5/24 (2006.01) A61P 15/18 (2006.01)

Patent

CA 2585334

The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical uses of these compounds are related to contraception, the treatment and/or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, or minication of side effects of cyclid menstrual bleeding. Additional uses of the invention include stimulation of food intake.

L'invention concerne de nouveaux dérivés d'indole, des compositions pharmaceutiques les contenant et leur utilisation dans le traitement ou la prévention de troubles ou de maladies induites par des agonistes et des antagonistes du récepteur de progestérone. Les utilisations cliniques de ces composés sont en rapport avec la contraception, le traitement et/ou la prévention de l'aménorrhée secondaire, la ménométroragie, la léiomyomatose utérine, l'endométriose utérine, le syndrome de Stein-Leventhal, les carcinomes et les adénocarcinomes de l'endomètre, des ovaires, de la poitrine, du colon, de la prostate, ou la réduction des effets secondaires des saignements du cycle menstruel. Parmi d'autres utilisations de l'invention, on peut citer la stimulation d'ingestion d'aliments.

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