Indole derivatives useful for the treatment of cns disorders

Details Indole derivatives useful for the treatment of cns disorders Indole derivatives useful for the treatment of cns disorders

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4045 (2006.01) A61K 31/4523 (2006.01) A61K 31/47 (2006.01) A61K 31/538 (2006.01) A61P 25/06 (2006.01) A61P 25/18 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) C07D 209/04 (2006.01) C07D 211/04 (2006.01) C07D 215/00 (2006.01) C07D 217/00 (2006.01) C07D 265/38 (2006.01) C07D 401/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2414115

The present invention relates to dopamine and serotonin receptor ligands having the general formula (I) wherein one of Y1 and Y2 is N, which is bound to Z, and the further meanings of Y1, Y2, Y3, Y4, Z, W, n, m, X, R and R1-R12 are as given in the claims and the description. The compounds of the invention are useful in the treatment of certain psychiatric and neurological disorders, i. e. schizophrenia and other psychoses, anxiety disorders, depression, migraine, cognitive disorders, ADHD and sleep improvement.

L'invention concerne des ligands du récepteur de la dopamine et de la sérotonine représentés par la formule (I) dans laquelle un parmi Y?1¿ et Y?2¿ représente N, lequel est lié à Z, et Y?1¿, Y?2¿, Y?3¿, Y?4¿, Z, W, n, m, X, R et R?1¿-R?12¿ ont la signification indiquée dans les revendications et le descriptif. Les composés selon l'invention conviennent pour améliorer la qualité du sommeil et pour traiter certains troubles psychiatriques et neurologiques, notamment la schizophrénie et autres psychoses, les troubles anxieux, la dépression, la migraine, les troubles cognitifs et le trouble déficitaire de l'attention avec hyperactivité.

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