Indole derivatives useful for the treatment of cns disorders

Details Indole derivatives useful for the treatment of cns disorders Indole derivatives useful for the treatment of cns disorders

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4045 (2006.01) A61K 31/4523 (2006.01) A61P 25/00 (2006.01) C07D 401/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2416212

The present invention relates to dopamine and serotonin receptor ligands having the general formula (I) Image wherein the meaning of R1-R6, W. n and X are as given in the claims and the description. The compounds of the invention are useful in the treatment of certain psychiatric and neurological disorders, i.e. schizophrenia, other psychoses, anxiety disorders, depression, migraine, cognitive disorders, ADHD and sleep improvement.

L'invention concerne des ligands de récepteur de dopamine et de sérotonine représentés par la formule générale (I), les significations de R<1>-R<9>, W, n et X étant données dans les revendications et la description. Les composés de cette invention sont utiles dans le traitement de certains troubles psychiatriques et neurologiques tels que la schizophrénie, d'autres psychoses, les troubles d'angoisse, la dépression, la migraine, les troubles cognitifs, le trouble déficitaire de l'attention avec hyperactivité et permettent d'améliorer le sommeil.

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