Indole derivatives useful for the treatment of cns disorders

Details Indole derivatives useful for the treatment of cns disorders Indole derivatives useful for the treatment of cns disorders

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/47 (2006.01) A61K 31/538 (2006.01) A61P 25/06 (2006.01) A61P 25/18 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) C07D 413/14 (2006.01) C07D 209/04 (2006.01) C07D 211/04 (2006.01) C07D 215/00 (2006.01) C07D 217/00 (2006.01) C07D 265/38 (2006.01)

Patent

CA 2411412

The present invention relates to dopamine and serotonin receptor ligands having the general formula (I) wherein one of Y1 and Y2 is N, which is bound to Y4, Y3 is Z-CH2, CH2-Z or CH2CH2 and the further meanings of Y1, Y2, Y3, Y4, Z, W, n, m, X, R1-R9 and R10 are as given in the claims and the description. The compounds of the invention are useful in the treatment of certain psychiatric and neurological disorders, i.e. schizophrenia, other psychoses, anxiety disorders, depression, migraine, cognitive disorders, ADHD and sleep improvement.

La présente invention concerne des ligands des récepteurs de la dopamine et de la sérotonine représentés par la formule générale (I) dans laquelle Y?1¿ et/ou Y?2¿ représente N, qui est lié à Y?4¿, Y?3¿ représente Z-CH¿2?, CH¿2?-Z ou CH¿2?CH¿2 ?;Y?1¿, Y?2¿, Y?3¿, Y?4¿, Z, W, n, m, X, R?1¿-R?9¿ et R?10¿ étant tels que décrits dans les revendications et le descriptif de l'invention. On utilise les composés de l'invention dans le traitement de certains troubles d'ordre psychiatrique et neurologique, à savoir, la schizophrénie, d'autres psychoses, les troubles de l'anxiété, la dépression, la migraine, les troubles cognitifs, l'hyperactivité avec déficit de l'attention (THADA), et dans l'amélioration du sommeil.

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