Indole spla2 inhibitors

Details Indole spla2 inhibitors Indole spla2 inhibitors

A - Human Necessities

61

K

A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 205/02 (2006.01) C07D 209/04 (2006.01) C07D 209/12 (2006.01) C07D 209/14 (2006.01) C07D 209/18 (2006.01) C07D 209/22 (2006.01) C07D 209/82 (2006.01) C07D 211/26 (2006.01) C07D 211/30

Patent

CA 2338727

A class of novel acylsulfonamide substituted indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases such as septic shock.

La présente invention concerne une classe de composés indoles à substitution acylsulfonamide ainsi que l'utilisation de tels composés pour inhiber la libération d'acides gras par médiation des sPLA¿2? en vue du traitement d'affections inflammatoires telles que le choc septique.

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