Indole-type derivatives as inhibitors of p38 kinase

Details Indole-type derivatives as inhibitors of p38 kinase Indole-type derivatives as inhibitors of p38 kinase

C - Chemistry, Metallurgy

07

D

C07D 409/14 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 209/18 (2006.01) C07D 209/42 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2497408

The invention is directed to methods to inhibit p38-.alpha. kinase using compounds comprising a phenyl or thienyl coupled through a piperidine or piperazine nucleus to an indole residue wherein the indole residue mandatorily has a substituent on the ring nitrogen which is an amino or substituted amino group.

Cette invention concerne des procédés permettant d'inhiber la kinase p38-.alpha. au moyen de composés comprenant un phényle ou un thiényle couplé par un noyau pipéridine ou pipérazine à un résidu indole, lequel résidu indole comprend obligatoirement un substituant sur le cycle azote qui est un groupe amino ou un groupe amino substitué.

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