C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/240, 260/207
C07D 401/12 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2031667
ABSTRACT The present invention relates to an indoleacetic acid derivative and a salt thereof expressed by the following formula (I): Image (I) [wherein X denotes a piperidino group, 1-pyrrolidinyl group or 3-hydroxy-1-pyrrolidinyl group; Y denotes Image (wherein R1 denotes a hydrogen atom or a lower alkyl group, and 1 denotes 0, 1 or 2) or Image (wherein R2 denotes a hydrogen atom, a lower alkyl group or a hydroxyl group, m denotes 0, 1 or 2, and n denotes 1, 2 or 3)]. The present invention also relates to anti-inflammatory drugs, anti- rheumatic drugs and anti-ulcer drugs containing the above compounds as active ingredients. The compounds possess a strong antiinflammatory action while causing extremely reduced troubles of digestive organs which is a serious defect with conventional non-steroidal anti-inflammatory drugs, and possess an excellent anti-ulcer action as well.
Arai Heihachiro
Ueda Ikuo
Gowling Lafleur Henderson Llp
Zeria Pharmaceutical Co. Ltd.
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