Indolecarboxylic compounds and their use as pharmaceutical...

C - Chemistry – Metallurgy – 07 – D

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C07D 209/42 (2006.01) A61K 31/40 (2006.01) C07D 209/60 (2006.01)

Patent

CA 2271085

The invention concerns the use as active principle, in a physiologically acceptable medium, in a composition, an efficient amount of at least one compound of the indolecarboxylic family, said compound or compositions being designed for treating disorders related to an over-activity of 5 alpha -reductase. Said compounds or compositions containing them are particularly designed for treating androgen-dependent disorders such as seborrhea and/or acne and/or hirsutism and/or androgenetic alopecia. The invention also concerns novel compounds of the indolecarboxylic family and compositions containing them.

L'invention concerne l'utilisation à titre de principe actif, dans un milieu physiologiquement acceptable, dans une composition, d'une quantité efficace d'au moins un composé de la famille des indole-carboxyliques de la formule générale (I): Image ce composé ou ces compositions étant destinés à traiter les désordres liés â une suractivité de la 5.alpha.-réductase. Ces composés ou les compositions les contenant sont plus particulièrement destinés à traiter les désordres androgéno-dépendants comme par exemple la séborrhée et/ou l'acné et/ou l'hirsutisme et/ou l'alopécie androgénétique. L'invention concerne également de nouveaux composés de la famille des indole-carboxyliques ainsi que les compositions les contenant.

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