Indoles

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C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) C07C 43/307 (2006.01) C07C 43/313 (2006.01) C07C 45/45 (2006.01) C07C 49/76 (2006.01) C07C 49/784 (2006.01) C07C 49/813 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2167397

Compounds of formula (I) and pharmaceutically acceptable salts thereof, where R is CO2R12 and R12 is H or a biolabile ester-forming group or R is tetrazol-5-yl and either (a) R1 is (Ia) and R2 is F, Cl, Br, I, CH3 or CF3 or (b) R1 is C3-C6 alkyl and R2 is C2-C4 alkyl, are selective 5-.alpha.-reductase-1 inhibitors.

L'invention concerne des composés selon la formule (I) et leurs sels pharmaceutiquement acceptables. Dans cette formule, R représente CO2R12 et R12 représente H ou un groupe formant un ester biolabile ou R représente tétrazole-5-yle et soit (a) R1 représente (Ia) et R2 représente F, Cl, Br, I, CH3 ou CF3 ou (b) R1 représente C3-C6 alkyle et R2 représente C2-C4 alkyle. Ces composés sont des inhibiteurs sélectifs de 5-alpha-réductase-1.

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