Indoles having anti-diabetic activity

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 413/04 (2006.01) A61K 31/42 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2495915

Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

L'invention concerne des indoles contenant des substituants d'acide aryloxyalcanoïque ou des substituants d'acide arylalcanoïque. Ces indoles constituent des agonistes ou agonistes partiels du PPAR gamma et sont utiles pour traiter et lutter contre l'hyperglycémie symptomatique du diabète de type II, la dyslipidémie, l'hyperlipidémie, l'hypercholestérolémie, et l'obésité fréquemment associées au diabète de type II.

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