A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/404 (2006.01) C07D 209/04 (2006.01)
Patent
CA 2571789
Indoles of Formula (I) having -X-aryl-(CH2)x#191-oxazolidinedione and -X- heteroaryl-(CH2)X-oxazolidinedione substituents on the N atom of the indole ring, where x is 0 or 1, and -X-is a bond or -CH2-, and their thiazolidinedione analogs, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.
L'invention concerne des indoles de formule (I) comportant des substituants de X-aryl-(CH2)x-oxazolidinediones et de X-hétéaryl-(CH2)x-oxazolidinediones sur l'atome de N du composé cyclique indole, X valant 0 ou 1, et X- désignant une liaison ou CH2-, ainsi que leurs analogues thiazolidinediones. Lesdits indoles sont des agonistes gamma du PPAR ou des agonistes partiels et s'utilisent dans le traitement et la régulation du diabète du type II, y compris l'hyperglycémie, la dyslipidémie, l'hyperlipidémie, l'hypercholestérolémie, l'hypertriglycéridémie et l'obésité, qui sont fréquemment associées au diabète de type 2.
Liu Kun
Meinke Peter T.
Wood Harold B.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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