C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/10 (2006.01) A61K 31/404 (2006.01) A61K 31/423 (2006.01) A61K 31/4439 (2006.01) A61P 3/10 (2006.01) C07D 209/12 (2006.01) C07D 401/04 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2495943
Indoles of formula I (see above formula) and pharmaceutically acceptable salts thereof, and which have aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.
L'invention concerne des indoles comprenant des substituants d'acide aryloxyalcanoïque ou des substituants d'acide arylalcanoïque, et constituant des agonistes ou des agonistes partiels du PPAR gamma, et utilisés dans le traitement et le contrôle de l'hyperglycémie symptomatique du diabète de type II, ainsi que de la dyslipidémie, l'hyperlipidémie, l'hypercholestérolémie, l'hypertriglycéridémie, et l'obésité souvent associées au diabète de type 2.
Acton John J. III
Black Regina M.
Debenham Sheryl D.
Liu Kun
Meinke Peter T.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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