Indoles useful as platelet activating factor antagonists

Details Indoles useful as platelet activating factor antagonists Indoles useful as platelet activating factor antagonists

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/44 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2100682

2100682 9214732 PCTABS00015 Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

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