C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/42 (2006.01) A61K 31/404 (2006.01) A61P 29/00 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2570531
There is provided a compound of formula: (I) wherein X, Rl, R2, R3, R4, R5, R6, R7 and R8 have meanings given in the description, and pharmaceutically- acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of microsomal prostaglandin E synthase-1 is desired and/or required, and particularly in the treatment of inflammation.
L'invention porte sur un composé de formule (I) dans laquelle: X, R?l¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿ et R?8¿ ont les significations données dans la description, et sur ses sels pharmacocompatibles, et qui s'avère utile pour traiter des maladies où l'on souhaite ou doit inhiber l'activité de la prostaglandine E synthase-1 microsomale, en particulier les inflammations.
Kalvins Ivars
Katkevics Martins
Olofsson Kristofer
Ozola Vita
Pelcman Benjamin
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Biolipox Ab
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