Indoles useful in the treatment of inflammation

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 403/04 (2006.01) A61K 31/404 (2006.01) A61P 29/00 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2528626

There is provided a compound of formula (I), wherein X, Y, Z, R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of microsomal prostaglandin E synthase-1 is desired and/or required, and particularly in the treatment of inflammation.

La présente invention concerne un composé représenté par la formule (I) dans laquelle X, Y, Z, R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ sont tels que définis dans la description, ainsi que des sels pharmaceutiquement acceptables de ce composé. Ces composés servent au traitement de maladies dans lesquelles l'inhibition de l'activité de la prostaglandine E synthase 1 microsomale est souhaitable et/ou requise et servent en particulier au traitement de l'inflammation.

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