C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4427 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2671324
The present invention is concerned with novel indol-2-yl-carbonyl-piperidin- benzoimidazolon and indol-2-yl-carbonyl-piperidin-benzoxazolon derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. Present invention comprises compounds of the general formula (I) wherein R1 to R11, X and Y are as defined in the specification.
La présente invention concerne les nouveaux dérivés d'indol-2-yl-carbonyl-pipéridin-benzoimidazolone et d'indol-2-yl-carbonyl-pipéridin-benzoxazolone comme antagonistes du récepteur V1a, leur fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme médicaments. Les composés actifs de la présente invention sont utiles dans la prévention et/ou le traitement de l'anxiété et de troubles dépressifs et d'autres maladies. La présente invention comprend des composés de formule générale (I) dans laquelle les R1 à R11, X et Y sont tels que définis dans la spécification.
Bissantz Caterina
Grundschober Christophe
Masciadri Raffaello
Ratni Hasane
Rogers-Evans Mark
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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