Indolin-2-one derivatives, process for their production and...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 209/96 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2235686

The subject of the invention is indolin-2-one derivatives of formula: IMG> in which: - W represents a-CH2- or -SO2- group; - Cy forms, with the carbon to which it is bonded, a non-aromatic, saturated or unsaturated C3-C12 hydrocarbon ring which is optionally condensed or substituted by one or a number of (Cl-C7)alkyl groups, it being possible for the said groups to substitute the same carbon atom one or a number of times, or by a C3-C6 spirocycloalkyl; - T represents a(Cl-C4)alkylene which is optionally interrupted by a (C3-C6)cycloalkylene, the said alkylenes optionally being substituted one or a number of times on the same carbon atom by a(Cl-C3)alkyl; or alternatively T represents a direct bond; - Z represents in particular an amino group; - Rl and R2, as well as R3 and R4, are either hydrogen or substituents, such as, for example, a halogen, an alkyl, and the like. Application: Medicines having an affinity for vasopressin and/or oxytocin receptors.

L'invention a pour objet des dérivés d'indolin-2-one de formule (I) dans laquelle W repésente un groupe -CH2- ou -SO2; Cy constitue avec le carbone auquel il est lié un cycle hydrocarboné non aromatique en C3-C12, saturé ou insaturé, éventuellement condensé ou susbtitué par un ou plusieurs groupes (C1-C7)alkyles, lesdits groupes pouvant substituer une ou plusieurs fois le même atome de carbone ou par un spirocycloalkyle en C3-C6; T représente un (C1-C4)alkylène éventuellement interrompu par un (C3-C6)cycloalkylène, lesdits alkylènes étant éventuellement substitués une ou plusieurs fois sur le même atome de carbone par un (C1-C3)alkyle; ou bien T représente une liaison directe; Z représente notamment un groupe amino; R1 et R2 ainsi que R3 et R4 sont soit l'hydrogène, soit des substituants, tels que par exemple un halogène, un alkyle, etc. Application: médicaments ayant une affinité pour les récepteurs de la vasopressine et/ou de l'ocytocine.

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