C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/044 (2006.01) A61K 31/40 (2006.01) C07D 307/79 (2006.01) C07D 311/58 (2006.01) C07D 313/08 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2179402
A compound of formula (I), wherein R1 is hydrogen, halogen or C1-6 alkyl; R2 is a group of the formula (I) -CR3R4(CH2)pNR5COR6; R3, R4 and R5, which may be the same or different, are hydrogen or C1-6alkyl; R6 is C1-6alkyl or C3-7 cycloalkyl; n is an integer of 2, 3 or 4; p is an integer of 1, 2, 3 or 4; and pharmaceutically acceptable salts and solvates thereof. A compound of formula (I) is useful in the treatment of conditions associated with a disturbed functioning of the melatonin system.
Composé de formule (I) ainsi que ses sels et solvates pharmaceutiquement acceptables. Dans cette formule, R?1¿ représente hydrogène, halogène ou alkyle C¿1-6?; R?2¿ est un groupe de formule -CR?3¿R?4¿(CH¿2?)¿p?NR?5¿COR?6¿; R?3¿, R?4¿ et R?5¿, qui peuvent être semblables ou différents, représentent hydrogène ou alkyle C¿1-6?; R?6¿ représente alkyle C¿1-6? ou cycloalkyle C¿3-7?; n est un nombre entier choisi entre 2, 3, ou 4; p est un nombre entier choisi entre 1, 2, 3, ou 4. Ce composé de la formule (I) est utile dans le traitement des états associés à un dysfonctionnement du système mélatonine.
Carter Malcolm Clive
North Peter Charles
Glaxo Group Limited
Swabey Ogilvy Renault
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